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The ability of HIV to persist within latent cellular reservoirs represents a major barrier to cure. The timing of establishment of individual viral reservoirs over the course of an infection may influence their susceptibility to elimination by immune-mediated or therapeutic approaches. However, methods to accurately estimate the age of reservoir sequences remain scarce. We propose a simple method to date suspected reservoir sequences using phylogenetically informed regression.
Our method is as follows: Taking aligned HIV sequences from a single individual sampled over multiple time points, we reconstruct a maximum-likelihood phylogeny. The location of the root in the phylogeny is determined using root-to-tip regression.
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Positive Singles, one of the leading services connecting daters living with venerial disease, has launched a new area of its site specifically catering to HIV-positive gay individuals. Members of the POZ gay community often find it difficult to connect with others online due to stigma associated with the disease.
Further, many may lack a support network where they can talk about their health and wellbeing. The new online space looks to help on both fronts, offering an inclusive environment for dating and active forums where users can discuss their experiences. Not only must you deal with the health consequences of your diagnosis, but having HIV can make it difficult to date. We have been dedicatedly working to successfully bring together POZ gay couples.
Positive Singles claims over 1,, registered members.